MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody
Basic information
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Name
MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody
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Price
362 EUR
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Size
0.1ml
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Catalog number
bsm-50345M
Detailed information
Long name
MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody
Also known as
MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody
Category
Primary Antibodies
Conjugation
Unconjugated
Target Antigen
MEK6 (MAP kinase kinase 6)
Specificity
This is a highly specific antibody against MEK6 (MAP kinase kinase 6).
Modification(s)
None
Modification site(s)
Unmodified antibody
Clonality
Monoclonal
Clone number
AF4G6
Concentration
2ug/ul
Source
Recombinant human protein purified from E.coli (His-MEK6)
Gene ID number
5608
Swiss Prot
P52564
Tested Applications
WB, IP
Recommended dilutions
WB (2.0 ug/ml) IP (2 ug)
Cross reactivity
Human
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Purification method
Purified by Protein G.
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names
MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; MAP2K6; SKK3
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
French translation
anticorps