anti-MAP4K4 Antibody
Basic information
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Name
anti-MAP4K4 Antibody
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Price
180 EUR
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Size
0.05 mg
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Catalog number
49-584
Detailed information
Gene info
MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.
Gene names
MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4
Antibodie's label
unlabelled serum
Purity
Purified
Ab raised in
Rabbit
Type
Polyclonal
Antigen
Peptide corresponding to amino acids 931 to 947 of human NIK.
Immuno application
Western Blot, immuno-histo-chemistry
Antibody advice
MAP4K4 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 ug/mL, and immunofluorescence starting at 10 ug/mL.
Suspention, pH, azide
PBS, 0.02% sodium azide.
Keep at
Store MAP4K4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.
Works with
Human
Omim nr
29427585
Ncbi nr
O95819
Vial with antibody
in solution
NCBI GENE nr
9448
GENE symbol
MAP4K4
Antigene name
mitogen-activated protein kinase kinase kinase kinase 4
Source
Homo sapiens
Protein nr
O95819
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps