anti-TAB1 Antibody
Basic information
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Name
anti-TAB1 Antibody
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Price
180 EUR
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Size
0.02 mg, 0.1 mg
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Catalog number
3387
Detailed information
Gene info
TAB1 Antibody: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.
Gene names
TAB1 Antibody: 3'-Tab1, MAP3K7IP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1
Antibodie's label
unlabelled serum
Purity
TAB1 Antibody is affinity chromatography purified via peptide column.
Ab raised in
Rabbit
Type
Polyclonal
Immunoglobulin
IgG
Antigen
TAB1 antibody was made against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.
Immuno application
ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
Antibody advice
TAB1 antibody can be used for the detection of TAB1 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 1 ug/mL. For immunofluorescence start at 2 ug/mL.
Suspention, pH, azide
TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.
Keep at
TAB1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Works with
Human, Mouse
Omim nr
5174703
Ncbi nr
NP_006107
Vial with antibody
in solution
Quantity per ml
1 mg/mL
NCBI GENE nr
10454
GENE symbol
MAP3K7IP1
Antigene name
mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Source
Homo sapiens
Protein nr
Q15750
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation
anticorps