MAP2K1 Polyclonal Antibody
Basic information
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Name
MAP2K1 Polyclonal Antibody
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Price
245 EUR
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Size
50 μg
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Catalog number
CAC07869
Detailed information
Other name
Dual specificity mitogen-activated protein kinase kinase 1,MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1,MAP2K1,MEK1,PRKMK1
Immunogen
Recombinant Human Dual specificity mitogen-activated protein kinase kinase 1 protein (2-79AA)
Verified reactivity
Human, Mouse
Verified applications
ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200
Raised in
Rabbit
Clonality
Polyclonal
Protein number
Q02750
Gene number
Please refer to GenBank
NCBI number
Please refer to NCBI
Purity
Protein G purified, >95%
Storage recommendation
Aliquot and store at -20°C. Minimize freezing and thawing.
Use before
1 year
Shipping requirements
Blue ice
Estimated production time
3-7 business days
Supplementary information
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
Notes
For research use only. Not for diagnostic procedures.
Properties
If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Group
Polyclonals and antibodies
About
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
French translation
anticorps