SB202190, p38 MAP kinase inhibitor
Basic information
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Name
SB202190, p38 MAP kinase inhibitor
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Price
149 EUR
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Size
5 mg
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Catalog number
SIH-473-5MG
Detailed information
Stock availabilitIn Stock
In Stock
CAS number
152121-30-7
Description
p38 MAP kinase inhibitor
Molecular weight
331,3 g/mol
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name
FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Product category
Small Molecules
Product type
Inhibitor
Chemical formula
C20H14FN3O
Origin
Synthetic
Purity pourcentage
≥98% (TLC)
Soluble in
Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate
Physical appearance
Pale yellow solid
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant
PubChem number
5353940
Scientific context
SB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.
Bibliography
1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420. 2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.
Release date
1-Oct-2014
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of SB202190 (SIH-473), a p38 MAP kinase inhibitor. CAS #: 152121-30-7. Molecular Formula: C20H14FN3O. Molecular Weight: 331.3 g/mol. Chemical structure of SB202190, a p38 MAP kinase inhibitor (SIH-473). CAS # 152121-30-7. Molecular Formula: C20H14FN3O.
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.005
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.