Anisomycin, p38 MAP kinase activator
Basic information
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Name
Anisomycin, p38 MAP kinase activator
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Price
223 EUR
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Size
50 mg
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Catalog number
SIH-266-50MG
Detailed information
Stock availabilitIn Stock
In Stock
CAS number
22862-76-6
Description
p38 MAP kinase activator
Molecular weight
265,31 g/mol
Primary research fields
Cancer, Apoptosis
Other name
(2S,3R,4R)-4-Hydroxy-2-(4-methoxybenzyl)-3-pyrrolidinyl acetate
Product category
Small Molecules
Product type
Activator
Chemical formula
C14H19NO4
Origin
Synthetic
Purity pourcentage
>98%
Soluble in
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Physical appearance
White solid
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 - Toxic by inhilation, in contact with skin and if swallowed Hazard Phrases: H301 Precautionary Phrases: P301 + P310
PubChem number
253602
Scientific context
Anisomycin is an antibiotic which inhibits protein synthesis (1). It interferes with protein and DNA synthesis by inhibiting peptidyl transferace on the 80S ribosome system. It can activate stress-activated protein kinases, MAPkinase and other signal transduction pathways.
Bibliography
1. Grollman A.P. (1967) J Biol Chem. 242(13): 3226-3233.
Release date
8-Apr-2011
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of Anisomycin (SIH-266), a Anoikis sensitizer. CAS #: 22862-76-6. Molecular Formula: C14H19NO4 . Molecular Weight: 265.31 g/mol. Chemical structure of Anisomycin, a Anoikis sensitizer (SIH-266). CAS # 22862-76-6. Molecular Formula: C14H19NO4 .
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.05