JX 401, p38 MAP kinase inhibitor
Basic information
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Name
JX 401, p38 MAP kinase inhibitor
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Price
717 EUR
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Size
50 mg
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Catalog number
SIH-454-50MG
Detailed information
Stock availabilitIn Stock
In Stock
CAS number
349087-34-9
Description
p38 MAP kinase inhibitor
Molecular weight
355,5 g/mol
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name
1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Product category
Small Molecules
Product type
Inhibitor
Chemical formula
C21H25NO2S
Origin
Synthetic
Purity pourcentage
≥98% (TLC)
Soluble in
Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml)
Physical appearance
Off-white solid
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number
1126109
Scientific context
JX 401 is a potent and reversible inhibitor of p38α. Specifically, it binds MAPK p38α. JX 401 is cell permeable.
Bibliography
1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405.
Release date
1-Oct-2014
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol. Chemical structure of JX 401, a p38alpha MAP kinase inhibitor (SIH-454). CAS # 349087-34-9. Molecular Formula: C21H25NO2S.
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.05
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.