SB203580, p38 MAP kinase inhibitor
Basic information
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Name
SB203580, p38 MAP kinase inhibitor
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Price
253 EUR
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Size
5 mg
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Catalog number
SIH-474-5MG
Detailed information
Stock availabilitIn Stock
In Stock
CAS number
152121-47-6
Description
p38 MAP kinase inhibitor
Molecular weight
377,4 g/mol
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name
4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole
Product category
Small Molecules
Product type
Inhibitor
Chemical formula
C21H16FN3OS
Origin
Synthetic
Purity pourcentage
≥98% (HPLC)
Soluble in
Soluble in DMSO (50 mg/ml)
Physical appearance
White to off-white powder
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H318 Causes serious eye damage. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously wit h water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/ physician. P330 Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant
PubChem number
176155
Scientific context
SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.
Bibliography
1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.
Release date
1-Oct-2014
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of SB203580 (SIH-474), a p38 MAP kinase inhibitor. CAS #: 152121-47-6. Molecular Formula: C21H16FN3OS. Molecular Weight: 377.4 g/mol. Chemical structure of SB203580, a p38 MAP kinase inhibitor (SIH-474). CAS # 152121-47-6. Molecular Formula: C21H16FN3OS.
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.005
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.