SR 3576, JNK3 kinase inhibitor
Basic information
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Name
SR 3576, JNK3 kinase inhibitor
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Price
241 EUR
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Size
5 mg
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Catalog number
SIH-513-5MG
Detailed information
Stock availabilitIn Stock
In Stock
CAS number
1164153-22-3
Description
JNK3 kinase inhibitor
Molecular weight
501,5 g/mol
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
Other name
SR3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
Product category
Small Molecules
Product type
Inhibitor
Chemical formula
C27H27N5O5
Origin
Synthetic
Purity pourcentage
≥98% (HPLC)
Soluble in
Soluble to 100 mM in DMSO
Physical appearance
Off White solid
Storage recommendations
-20ºC
Shipping recommendations
Shipped Ambient
Safety information
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
PubChem number
70702008
Scientific context
SR 3576 is a highly potent and selective JNK3 inhibitor. SR 3576 is a pyrazolourea compound and is cell-permeable.
Bibliography
1. Kamenecka T., et al. (2009) J. Biol. Chem. 284(19): 12853–12861.
Release date
1-Oct-2014
PubMed number
Refer to PubMed
Tested applications
To be tested
Tested reactivity
To be tested
Representative figure legend
Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol. Chemical structure of SR 3576, a JNK3 kinase inhibitor (SIH-513). CAS # 1164153-22-3. Molecular Formula: C27H27N5O5.
Warning information
Non-hazardous
Country of production
Canada
Total weight (kg)
0.25
Net weight (g)
0.005
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.