Anti-NFkB Inducing Kinase NIK, ALEXA Fluor 594
Basic information
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Name
Anti-NFkB Inducing Kinase NIK, ALEXA Fluor 594
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Price
489 EUR
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Size
100 microliters
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Catalog number
GENTObs-0074R-A594
Detailed information
Type
Conjugated Primary Antibody
Conjugated with
ALEXA FLUOR® 594
Host organism
Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide
NFkB Inducing Kinase NIK
Specificity
This antibody reacts specifically with NFkB Inducing Kinase NIK
Modification
No modification has been applied to this antibody
Modification site
None
Clonality
Polyclonal Antibody
Clone
Polyclonal Antibodies
Concentration
1ug per 1ul
Subcellular locations
Cytoplasm
Antigen Source
KLH conjugated synthetic peptide derived from human NIK
Gene ID
9020
Swiss Prot
Q99558
Applications
IF(IHC-P)
Applications with corresponding dilutions
IF(IHC-P)(1:50-200)
Cross reactive species
Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Cross Reactive Species details
No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Background information
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.
Purification method
Purified by Protein A.
Storage
Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Excitation emission
590nm/617nm
Synonyms
HS; NIK; HSNIK; FTDCR1B; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK; MAP3K14
Also known as
NFkB Inducing Kinase NIK Antibody
Other name
Anti-NFkB Inducing Kinase NIK
Advisory
Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Properties
For facs or microscopy Alexa 1 conjugate.
Conjugation
Alexa Fluor,ALEXA FLUOR® 594
Conjugated
Alexa conjugate 1
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory