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Basic information

  • Name

    MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody

  • Price

    362 EUR

  • Size

    0.1ml

  • Catalog number

    bsm-50345M

Detailed information

Long name

MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody

Also known as

MEK6 (MAP kinase kinase 6) (AF4G6) Monoclonal Antibody

Category

Primary Antibodies

Conjugation

Unconjugated

Target Antigen

MEK6 (MAP kinase kinase 6)

Specificity

This is a highly specific antibody against MEK6 (MAP kinase kinase 6).

Modification(s)

None

Modification site(s)

Unmodified antibody

Clonality

Monoclonal

Clone number

AF4G6

Concentration

2ug/ul

Source

Recombinant human protein purified from E.coli (His-MEK6)

Gene ID number

5608

Swiss Prot

P52564

Tested Applications

WB, IP

Recommended dilutions

WB (2.0 ug/ml) IP (2 ug)

Cross reactivity

Human

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Background of the target antigen

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Purification method

Purified by Protein G.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Synonym names

MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; MAP2K6; SKK3

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

French translation

anticorps