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Basic information

  • Name

    MAP3K4/MEK kinase-4 Antibody

  • Price

    263 EUR

  • Size

    0.1ml

  • Catalog number

    bs-11883R

Detailed information

Long name

MAP3K4/MEK kinase-4 Primary Polyclonal Antibody

Also known as

MAP3K4/MEK kinase-4 PAb

Category

Primary Antibodies

Conjugation

Unconjugated

Target Antigen

MAP3K4/MEK kinase-4

Specificity

This is a highly specific antibody against MAP3K4/MEK kinase-4.

Modification(s)

None

Modification site(s)

Unmodified antibody

Clonality

Polyclonal antibody

Clone number

Polyclonal antibody

Concentration

1ug per 1ul

Source

This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAP3K4/MEK kinase-4

Tested Applications

IHC-P, IF(IHC-P)

Recommended dilutions

IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Cross reactivity

Human, Mouse, Rat

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Background of the target antigen

Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 has been shown to phosphorylate MEK-1 via Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK path-way. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways.

Purification method

This antibody was purified via Protein A.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Synonym names

FLJ42439; KIAA0213; M3K4_HUMAN; MAP three kinase 1; MAP3K4; MAPK/ERK kinase kinase 4; MAPKKK4 antibodyMEK kinase 4; MEKK 4; MEKK4; Mitogen-activated protein kinase kinase kinase 4; MTK1; PRO0412; RP3-473J16.4

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps