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Basic information

  • Name

    MAPKAP kinase 5 (13H5) Monoclonal Antibody

  • Price

    362 EUR

  • Size

    0.1ml

  • Catalog number

    bsm-50252M

Detailed information

Long name

MAPKAP kinase 5 (13H5) Monoclonal Antibody

Also known as

MAPKAP kinase 5 (13H5) Monoclonal Antibody

Category

Primary Antibodies

Conjugation

Unconjugated

Target Antigen

MAPKAP kinase 5

Specificity

This is a highly specific antibody against MAPKAP kinase 5.

Modification(s)

None

Modification site(s)

Unmodified antibody

Clonality

Monoclonal

Clone number

13H5

Concentration

1ug per 1ul

Source

Recombinant human protein purified from E.coli (His-PRAK)

Gene ID number

8550

Swiss Prot

Q8IW41

Tested Applications

WB

Recommended dilutions

WB (0.5 ug/mL)

Cross reactivity

Human

Cross reactive species details

Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.

Background of the target antigen

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

Purification method

Purified by Protein G.

Storage conditions

Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.

Synonym names

MK5; MK-5; PRAK; MAPKAP-K5; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; MAPKAPK5

Properties

If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

French translation

anticorps