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Basic information

  • Name

    anti-MAP4K4 Antibody

  • Price

    180 EUR

  • Size

    0.05 mg

  • Catalog number

    49-584

Detailed information

Gene info

MAP4K4 is a MSN protein kinase. The protein has a structure similar to other GCK (Group I) kinases and contains two consensus SH3 binding motifs, which have been shown to interact with the SH3 domains of the SH2/SH3 adapter protein Nck. NIK can be activated by tumor necrosis factor (TNF)-alpha. Activated NIK has been shown to activate c-Jun N-terminal kinase (JNK) and to bind and activate the plasma membrane Na-H exchanger NHE1. In NIK(-/-) mice, mesodermal and endodermal cells of the primitive streak fail to migrate to their correct location, and embryos die between embryonic day (E) 9.5 and E10.5. At least three protein isoforms have been reported.

Gene names

MAP4K4, HGK, HPK/GCK-like kinase HGK, KIAA0687, Misshapen, NIK, Nck-interacting kinase, HPK/GCK-like kinase, Ste20 group protein kinase HGK, MEKKK 4, MEKKK4, Zc1, FLH21957, MEK kinase kinase 4

Antibodie's label

unlabelled serum

Purity

Purified

Ab raised in

Rabbit

Type

Polyclonal

Antigen

Peptide corresponding to amino acids 931 to 947 of human NIK.

Immuno application

Western Blot, immuno-histo-chemistry

Antibody advice

MAP4K4 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 ug/mL, and immunofluorescence starting at 10 ug/mL.

Suspention, pH, azide

PBS, 0.02% sodium azide.

Keep at

Store MAP4K4 antibody at 4 grades C or -20 grades C. As with all antibodies avoid freeze/thaw cycles.

Works with

Human

Omim nr

29427585

Ncbi nr

O95819

Vial with antibody

in solution

NCBI GENE nr

9448

GENE symbol

MAP4K4

Antigene name

mitogen-activated protein kinase kinase kinase kinase 4

Source

Homo sapiens

Protein nr

O95819

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps