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Basic information

  • Name

    anti-TAB1 Antibody

  • Price

    180 EUR

  • Size

    0.02 mg, 0.1 mg

  • Catalog number

    3387

Detailed information

Gene info

TAB1 Antibody: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.

Gene names

TAB1 Antibody: 3'-Tab1, MAP3K7IP1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAK1-binding protein 1

Antibodie's label

unlabelled serum

Purity

TAB1 Antibody is affinity chromatography purified via peptide column.

Ab raised in

Rabbit

Type

Polyclonal

Immunoglobulin

IgG

Antigen

TAB1 antibody was made against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.

Immuno application

ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence

Antibody advice

TAB1 antibody can be used for the detection of TAB1 by Western blot at 0.5 to 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 1 ug/mL. For immunofluorescence start at 2 ug/mL.

Suspention, pH, azide

TAB1 Antibody is supplied in PBS containing 0.02% sodium azide.

Keep at

TAB1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Works with

Human, Mouse

Omim nr

5174703

Ncbi nr

NP_006107

Vial with antibody

in solution

Quantity per ml

1 mg/mL

NCBI GENE nr

10454

GENE symbol

MAP3K7IP1

Antigene name

mitogen-activated protein kinase kinase kinase 7 interacting protein 1

Source

Homo sapiens

Protein nr

Q15750

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps