Need help?

+390236006593Hours: 8am-7pm M-Fri

Basic information

  • Name

    MAP2K1 Polyclonal Antibody

  • Price

    245 EUR

  • Size

    50 μg

  • Catalog number

    CAC07869

Detailed information

Other name

Dual specificity mitogen-activated protein kinase kinase 1,MAP kinase kinase 1,MAPKK 1,MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1,MAP2K1,MEK1,PRKMK1

Immunogen

Recombinant Human Dual specificity mitogen-activated protein kinase kinase 1 protein (2-79AA)

Verified reactivity

Human, Mouse

Verified applications

ELISA,WB,IHC. Recommended dilution:WB:1:500-1:5000,IHC:1:20-1:200

Raised in

Rabbit

Clonality

Polyclonal

Protein number

Q02750

Gene number

Please refer to GenBank

NCBI number

Please refer to NCBI

Purity

Protein G purified,>95%

Storage recommendation

Aliquot and store at -20°C. Minimize freezing and thawing.

Use before

1 year

Shipping requirements

Blue ice

Estimated production time

3-7 business days

Supplementary information

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Notes

For research use only. Not for diagnostic procedures.

Properties

If you buy Antibodies supplied by bioma they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Group

Polyclonals and antibodies

About

Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.

French translation

anticorps