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Basic information

  • Name

    Doramapimod, p38 MAP kinase inhibitor

  • Price

    427 EUR

  • Size

    25 mg

  • Catalog number

    SIH-442-25MG

Detailed information

Stock availabilitIn Stock

In Stock

CAS number

285983-48-4

Description

p38 MAP kinase inhibitor

Molecular weight

527,7 g/mol

Primary research fields

Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors

Other name

JNK Inhibitor XVII, BIRB796, 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

Product category

Small Molecules

Product type

Inhibitor

Chemical formula

C31H37N5O3

Origin

Synthetic

Purity pourcentage

≥99% (HPLC)

Soluble in

Soluble in DMSO

Physical appearance

White solid

Storage recommendations

-20ºC

Shipping recommendations

Shipped Ambient

Safety information

Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

PubChem number

156422

Scientific context

Doramapimod is a highly potent and selective inhibitor of p38α MAPK. It specifically blocks TNFα release.

Bibliography

1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272.

Release date

1-Oct-2014

PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of Doramapimod (SIH-442), a p38 MAP kinase inhibitor. CAS #: 285983-48-4. Molecular Formula: C31H37N5O3. Molecular Weight: 527.7 g/mol. Chemical structure of Doramapimod, a p38 MAP kinase inhibitor (SIH-442). CAS # 285983-48-4. Molecular Formula: C31H37N5O3.

Warning information

Non-hazardous

Country of production

Canada

Total weight (kg)

0.25

Net weight (g)

0.025

Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.