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Basic information

  • Name

    JX 401, p38 MAP kinase inhibitor

  • Price

    717 EUR

  • Size

    50 mg

  • Catalog number


Detailed information

Stock availabilitIn Stock

In Stock

CAS number



p38 MAP kinase inhibitor

Molecular weight

355,5 g/mol

Primary research fields

Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors

Other name


Product category

Small Molecules

Product type


Chemical formula




Purity pourcentage

≥98% (TLC)

Soluble in

Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml)

Physical appearance

Off-white solid

Storage recommendations


Shipping recommendations

Shipped Ambient

Safety information

Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

PubChem number


Scientific context

JX 401 is a potent and reversible inhibitor of p38α. Specifically, it binds MAPK p38α. JX 401 is cell permeable.


1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405.

Release date


PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol. Chemical structure of JX 401, a p38alpha MAP kinase inhibitor (SIH-454). CAS # 349087-34-9. Molecular Formula: C21H25NO2S.

Warning information


Country of production


Total weight (kg)


Net weight (g)


Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.