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Basic information

  • Name

    SB202190, p38 MAP kinase inhibitor

  • Price

    427 EUR

  • Size

    25 mg

  • Catalog number


Detailed information

Stock availabilitIn Stock

In Stock

CAS number



p38 MAP kinase inhibitor

Molecular weight

331,3 g/mol

Primary research fields

Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors

Other name

FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

Product category

Small Molecules

Product type


Chemical formula




Purity pourcentage

≥98% (TLC)

Soluble in

Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate

Physical appearance

Pale yellow solid

Storage recommendations


Shipping recommendations

Shipped Ambient

Safety information

Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well - ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P321 Specific treatment (see supplemental first aid instru ctions on this label). P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant

PubChem number


Scientific context

SB202190 is a highly selective and potent inhibitor of p38 MAP kinase. Specifically, it binds within the ATP pocket of the active kinase and selectively inhibits the p38α and β isoforms. It has been shown to induce apoptosis. SB202190 is cell-permeable.


1. Nemoto S., Xiang J., Huang S., & Lin A. (1998) J. Bio. Chem. 273(26): 16415–16420. 2. Karahashi H., Nagata K., Ishii K., & Amano F. (2000) Biochimica Et Biophysica Acta. 1502(2): 207–223.

Release date


PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of SB202190 (SIH-473), a p38 MAP kinase inhibitor. CAS #: 152121-30-7. Molecular Formula: C20H14FN3O. Molecular Weight: 331.3 g/mol. Chemical structure of SB202190, a p38 MAP kinase inhibitor (SIH-473). CAS # 152121-30-7. Molecular Formula: C20H14FN3O.

Warning information


Country of production


Total weight (kg)


Net weight (g)


Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.