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Basic information

  • Name

    SB203580, p38 MAP kinase inhibitor

  • Price

    253 EUR

  • Size

    5 mg

  • Catalog number


Detailed information

Stock availabilitIn Stock

In Stock

CAS number



p38 MAP kinase inhibitor

Molecular weight

377,4 g/mol

Primary research fields

Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors

Other name


Product category

Small Molecules

Product type


Chemical formula




Purity pourcentage

≥98% (HPLC)

Soluble in

Soluble in DMSO (50 mg/ml)

Physical appearance

White to off-white powder

Storage recommendations


Shipping recommendations

Shipped Ambient

Safety information

Classification: Acute toxicity, Oral (Category 4), H302 Serious eye damage (Category 1), H318 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 Harmful if swallowed. H318 Causes serious eye damage. Precautionary statements: P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously wit h water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER or doctor/ physician. P330 Rinse mouth. P501 Dispose of contents/ container to an approved waste disposal plant

PubChem number


Scientific context

SB203580 is a a pyridinyl imidazole that inhibits p38 MAP kinase. SB 203580 has also been shown to inhibit heat shock protein 27 (HSP 27) phosphorylation and has been shown to induce the activation of Raf-1. It displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. SB203580 is cell permeable.


1. Hall-Jackson C. A., Goedert M., Hedge P., & Cohen P. (1999) Oncogene. 18(12): 2047–2054. 2. Saklatvala, J., et al. (1996) J. Bio. Chem. 271(12): 6586–6589. 3. Cuenda A., et al. (1995) FEBS Letters. 364(2): 229–233.

Release date


PubMed number

Refer to PubMed

Tested applications

To be tested

Tested reactivity

To be tested

Representative figure legend

Chemical structure of SB203580 (SIH-474), a p38 MAP kinase inhibitor. CAS #: 152121-47-6. Molecular Formula: C21H16FN3OS. Molecular Weight: 377.4 g/mol. Chemical structure of SB203580, a p38 MAP kinase inhibitor (SIH-474). CAS # 152121-47-6. Molecular Formula: C21H16FN3OS.

Warning information


Country of production


Total weight (kg)


Net weight (g)


Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.