SR 3576, JNK3 kinase inhibitor
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JNK3 kinase inhibitor
Primary research fields
Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
SR3576, 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide
Soluble to 100 mM in DMSO
Off White solid
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
SR 3576 is a highly potent and selective JNK3 inhibitor. SR 3576 is a pyrazolourea compound and is cell-permeable.
1. Kamenecka T., et al. (2009) J. Biol. Chem. 284(19): 12853–12861.
Refer to PubMed
To be tested
To be tested
Representative figure legend
Chemical structure of SR 3576 (SIH-513), a JNK3 kinase inhibitor. CAS #: 1164153-22-3. Molecular Formula: C27H27N5O5. Molecular Weight: 501.5 g/mol. Chemical structure of SR 3576, a JNK3 kinase inhibitor (SIH-513). CAS # 1164153-22-3. Molecular Formula: C27H27N5O5.
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Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.