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Basic information

  • Name

    NIK Antibody (Nck-interacting kinase)

  • Price

    406 EUR

  • Size

    0.4 ml

  • Catalog number

    F50948-0.4ML

Detailed information

Category

Antibody

Concentration

In 1X PBS, pH 7.4, with 0.09% sodium azide

Form

Purified

Conjugation

Unconjugated

Clone

Polyclonal antibody

Recognised antigen

NIK (Nck-interacting kinase)

Host animal

Rabbit (Oryctolagus cuniculus)

Clonality

Polyclonal (rabbit origin)

Species reactivity

Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.

Tested applications

WB, ELISA

Recommended dilutions

Western blot: 1:1000

Notes

Titration of the NIK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Intented use

This NIK antibodyis to be used only for research purposes and not for diagnostics..

Uniprot #

O95819

Purity

Purified

Description

HGK/NIK, a member of the STE20 subfamily of Ser/Thr protein kinases, may play a role in the response to environmental stress and cytokines such as TNF-alpha. It appears to act upstream of the JUN N-terminal pathway. This protein is thought to interact with the SH3 domain of the adapter proteins Nck. HGK/NIK binds, via its CNH regulatory domain, to the N-terminal region of SPG3A. Expression appears to be ubiquitous, expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain, and isoform 4 is predominant in the liver, skeletal muscle and placenta.

Immunogen

A portion of amino acids 618-649 from the human protein was used as the immunogen for this NIK antibody.

Storage

Aliquot the NIK antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.

Properties

If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

French translation

anticorps