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Basic information

  • Name

    Anti-NFkB Inducing Kinase NIK, ALEXA Fluor 594

  • Price

    489 EUR

  • Size

    100 microliters

  • Catalog number

    GENTObs-0074R-A594

Detailed information

Type

Conjugated Primary Antibody

Conjugated with

ALEXA FLUOR® 594

Host organism

Rabbit (Oryctolagus cuniculus)

Target Protein/Peptide

NFkB Inducing Kinase NIK

Specificity

This antibody reacts specifically with NFkB Inducing Kinase NIK

Modification

No modification has been applied to this antibody

Modification site

None

Clonality

Polyclonal Antibody

Clone

Polyclonal Antibodies

Concentration

1ug per 1ul

Subcellular locations

Cytoplasm

Antigen Source

KLH conjugated synthetic peptide derived from human NIK

Gene ID

9020

Swiss Prot

Q99558

Applications

IF(IHC-P)

Applications with corresponding dilutions

IF(IHC-P)(1:50-200)

Cross reactive species

Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)

Cross Reactive Species details

No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.

Background information

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P1, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Purification method

Purified by Protein A.

Storage

Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.

Excitation emission

590nm/617nm

Synonyms

HS; NIK; HSNIK; FTDCR1B; Mitogen-activated protein kinase kinase kinase 14; NF-kappa-beta-inducing kinase; Serine/threonine-protein kinase NIK; MAP3K14

Also known as

NFkB Inducing Kinase NIK Antibody

Other name

Anti-NFkB Inducing Kinase NIK

Advisory

Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Properties

For facs or microscopy Alexa 1 conjugate.

Conjugation

Alexa Fluor,ALEXA FLUOR® 594

Conjugated

Alexa conjugate 1

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Gene

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory